Multiscale aspects of generation of high-gamma activity during seizures in human neocortex

TL Eissa, AK Tryba, CJ Marcuccilli, F Ben-Mabrouk… - Eneuro, 2016 - eneuro.org
High-gamma (HG; 80-150 Hz) activity in macroscopic clinical records is considered a marker
for critical brain regions involved in seizure initiation; it is correlated with pathological …

Tracking multisite seizure propagation using ictal high-gamma activity

S Tobochnik, LM Bateman, CI Akman… - Journal of Clinical …, 2022 - journals.lww.com
Purpose: Spatial patterns of long-range seizure propagation in epileptic networks have not
been well characterized. Here, we use ictal high-gamma activity (HGA) as a proxy of intense …

Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone

L Ren, MT Kucewicz, J Cimbalnik, JY Matsumoto… - Neurology, 2015 - AAN Enterprises
Objective: To investigate the generation, spectral characteristics, and potential clinical
significance of brain activity preceding interictal epileptiform spike discharges (IEDs) …

Cortical activation in generalized seizures

L Ding, S Satish, C Zhou, MJ Gallagher - Epilepsia, 2019 - Wiley Online Library
Objective Patients with generalized epilepsy exhibit different epileptiform events including
asymptomatic interictal spikes (IS), absence seizures with spike‐wave discharges (SWD s) …

[HTML][HTML] Local changes in neocortical circuit dynamics coincide with the spread of seizures to thalamus in a model of epilepsy

FB Neubauer, A Sederberg, JN MacLean - Frontiers in neural circuits, 2014 - frontiersin.org
During the generalization of epileptic seizures, pathological activity in one brain area
recruits distant brain structures into joint synchronous discharges. However, it remains …

Ictal high-gamma oscillation (60–99 Hz) in intracranial electroencephalography and postoperative seizure outcome in neocortical epilepsy

SC Park, SK Lee, H Che, CK Chung - Clinical neurophysiology, 2012 - Elsevier
OBJECTIVE: High-gamma oscillations (HGOs)(60–99Hz) have been suggested to correlate
with seizure onset zones and seizure outcomes. We investigated the correlation between …

[HTML][HTML] Distinguishing mechanisms of gamma frequency oscillations in human current source signals using a computational model of a laminar neocortical network

S Lee, SR Jones - Frontiers in human neuroscience, 2013 - frontiersin.org
Gamma frequency rhythms have been implicated in numerous studies for their role in
healthy and abnormal brain function. The frequency band has been described to …

Network asynchrony underlying increased broadband gamma power

N Guyon, LR Zacharias, EF de Oliveira… - Journal of …, 2021 - Soc Neuroscience
Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV)
underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is …

Neocortical gamma oscillations in idiopathic generalized epilepsy

K Benedek, A Berényi, P Gombkötő, H Piilgaard… - …, 2016 - Wiley Online Library
Objective Absence seizures in patients with idiopathic generalized epilepsy (IGE) may in
part be explained by a decrease in phasic GABAA (type‐A γ‐aminobutyric acid) receptor …

[HTML][HTML] Interaction between synaptic inhibition and glial-potassium dynamics leads to diverse seizure transition modes in biophysical models of human focal seizures

EC Y. Ho, W Truccolo - Journal of Computational Neuroscience, 2016 - Springer
How focal seizures initiate and evolve in human neocortex remains a fundamental problem
in neuroscience. Here, we use biophysical neuronal network models of neocortical patches …