Variability in state-dependent plasticity of intrinsic properties during cell-autonomous self-regulation of calcium homeostasis in hippocampal model neurons

S Srikanth, R Narayanan - ENeuro, 2015 - eneuro.org
How do neurons reconcile the maintenance of calcium homeostasis with perpetual switches
in patterns of afferent activity? Here, we assessed state-dependent evolution of calcium …

[HTML][HTML] Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium

S Srikanth, R Narayanan - Frontiers in cellular neuroscience, 2023 - ncbi.nlm.nih.gov
How do neurons that implement cell-autonomous self-regulation of calcium react to
knockout of individual ion-channel conductances? To address this question, we used a …

[PDF][PDF] Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells

P Mishra, R Narayanan - Iscience, 2022 - cell.com
Plasticity in the brain is ubiquitous. How do neurons and networks encode new information
and simultaneously maintain homeostasis in the face of such ubiquitous plasticity? Here, we …

Frequency-dependent gating of hippocampal–neocortical interactions

A Moreno, RGM Morris, S Canals - Cerebral Cortex, 2016 - academic.oup.com
How and where hippocampal–neocortical interactions required for memory formation take
place is a major issue of current research. Using a combined in vivo functional magnetic …

Inactivating ion channels augment robustness of subthreshold intrinsic response dynamics to parametric variability in hippocampal model neurons

RK Rathour, R Narayanan - The Journal of physiology, 2012 - Wiley Online Library
Key points• Voltage‐gated ion channels (VGICs) play a critical role in determining how
neurons respond to oscillatory inputs at various frequencies. How do inactivating VGICs …

Dynamical response properties of neocortical neurons to conductance‐driven time‐varying inputs

D Linaro, I Biró, M Giugliano - European Journal of …, 2018 - Wiley Online Library
Ensembles of cortical neurons can track fast‐varying inputs and relay them in their spike
trains, far beyond the cut‐off imposed by membrane passive electrical properties and mean …

[HTML][HTML] Active hippocampal networks undergo spontaneous synaptic modification

M Tsukamoto-Yasui, T Sasaki, W Matsumoto… - PloS one, 2007 - journals.plos.org
The brain is self-writable; as the brain voluntarily adapts itself to a changing environment,
the neural circuitry rearranges its functional connectivity by referring to its own activity. How …

Conditioning by subthreshold synaptic input changes the intrinsic firing pattern of CA3 hippocampal neurons

S Soldado-Magraner, F Brandalise… - Journal of …, 2020 - journals.physiology.org
Unlike synaptic strength, intrinsic excitability is assumed to be a stable property of neurons.
For example, learning of somatic conductances is generally not incorporated into …

Interplay between population firing stability and single neuron dynamics in hippocampal networks

E Slomowitz, B Styr, I Vertkin, H Milshtein-Parush… - Elife, 2015 - elifesciences.org
Neuronal circuits' ability to maintain the delicate balance between stability and flexibility in
changing environments is critical for normal neuronal functioning. However, to what extent …

[HTML][HTML] Regulation of hippocampal gamma oscillations by modulation of intrinsic neuronal excitability

A Klemz, F Wildner, E Tütüncü… - Frontiers in Neural Circuits, 2022 - frontiersin.org
Ion channels activated around the subthreshold membrane potential determine the
likelihood of neuronal firing in response to synaptic inputs, a process described as intrinsic …