Activation of a habenulo–raphe circuit is critical for the behavioral and neurochemical consequences of uncontrollable stress in the male rat

SD Dolzani, MV Baratta, J Amat, KL Agster… - eneuro, 2016 - eneuro.org
Exposure to uncontrollable stress [inescapable tailshock (IS)] produces behavioral changes
that do not occur if the stressor is controllable [escapable tailshock (ES)] an outcome that is …

The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress

J Amat, PD Sparks, P Matus-Amat, J Griggs… - Brain research, 2001 - Elsevier
Previous research indicates that the serotonergic neurons of the caudal dorsal raphe
nucleus (DRN) are activated to a greater degree by inescapable shock (IS) as compared to …

The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior

GI Elmer, H Palacorolla, CL Mayo, PL Brown… - Behavioural Brain …, 2019 - Elsevier
A growing body of clinical and preclinical research suggests that structural and functional
changes in the habenula, a component of the epithalamus, are associated with major …

Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus

RR Rozeske, AK Evans, MG Frank… - Journal of …, 2011 - Soc Neuroscience
Uncontrollable stressors produce behavioral changes that do not occur if the organism can
exercise behavioral control over the stressor. Previous studies suggest that the behavioral …

[HTML][HTML] The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter

RLH Pobbe, H Zangrossi Jr - Neuroscience letters, 2010 - Elsevier
Chemical stimulation of the lateral nucleus of the habenula (LHb), an area implicated in the
regulation of serotonergic activity in raphe nuclei, affects the acquisition of inhibitory …

[PDF][PDF] Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Z Zheng, C Guo, M Li, L Yang, P Liu, X Zhang, Y Liu… - Neuron, 2022 - cell.com
Chronic stress is a major risk factor for depression onset. However, it remains unclear how
repeated stress sculpts neural circuits and finally elicits depression. Given the essential role …

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

H Zhang, K Li, HS Chen, SQ Gao, ZX Xia… - Brain Structure and …, 2018 - Springer
Hypofunction of the serotonergic (5-HT) system has close relationship with the symptoms in
major depressive disorders (MDD), however, the underlying neural circuitry mechanisms are …

Lateral habenular norepinephrine contributes to states of arousal and anxiety in male rats

EM Purvis, AK Klein, A Ettenberg - Behavioural brain research, 2018 - Elsevier
Recent research has identified the lateral habenula (LHb) as a brain region playing an
important role in the production of stressful and anxiogenic states. Additionally …

[PDF][PDF] The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain

XY Wang, X Xu, R Chen, WB Jia, PF Xu, XQ Liu… - Cell Reports, 2023 - cell.com
Chronic stress and chronic pain are two major predisposing factors to trigger depression.
Enhanced excitatory input to the lateral habenula (LHb) has been implicated in the …

Selective activation of dorsal raphe nucleus‐projecting neurons in the ventral medial prefrontal cortex by controllable stress

MV Baratta, CM Zarza, DM Gomez… - European Journal of …, 2009 - Wiley Online Library
Exposure to uncontrollable stressors produces a variety of behavioral consequences (eg
exaggerated fear, reduced social exploration) that do not occur if the stressor is controllable …