Sex steroids do not modulate TRPM2-mediated injury in females following middle cerebral artery occlusion

N Quillinan, H Grewal, J Klawitter, PS Herson - eneuro, 2014 - eneuro.org
Calcium-permeable transient receptor potential M2 (TRPM2) ion channel activation
contributes to cerebral ischemic injury specifically in males. In male mice, circulating …

Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury

T Shimizu, TA Macey, N Quillinan… - Journal of Cerebral …, 2013 - journals.sagepub.com
The calcium-permeable transient receptor potential M2 (TRPM2) ion channel was recently
demonstrated to have a sexually dimorphic contribution to ischemic brain injury, with …

Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke

J Jia, S Verma, S Nakayama… - Journal of Cerebral …, 2011 - journals.sagepub.com
The calcium-permeable transient receptor potential M2 (TRPM2) ion channel is activated
following oxidative stress and has been implicated in ischemic damage; however, little …

Sexually dimorphic response of TRPM2 inhibition following cardiac arrest-induced global cerebral ischemia in mice

S Nakayama, R Vest, RJ Traystman… - Journal of Molecular …, 2013 - Springer
Transient global cerebral ischemia due to cardiac arrest followed by resuscitation (CA/CPR)
causes significant neurological damage in vulnerable neuron populations within the brain …

Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia

T Shimizu, RM Dietz, I Cruz-Torres, F Strnad… - Experimental …, 2016 - Elsevier
Introduction TRPM2 channels have been suggested to play a role in ischemic neuronal
injury, specifically in males. A major hindrance to TRPM2 research has been the lack of …

TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death

S Verma, N Quillinan, YF Yang, S Nakayama… - Neuroscience …, 2012 - Elsevier
Hippocampal CA1 neurons are particularly sensitive to ischemic damage, such as
experienced following cardiac arrest and cardiopulmonary resuscitation. In recent years …

Reversal of global ischemia-induced cognitive dysfunction by delayed inhibition of TRPM2 ion channels

RM Dietz, I Cruz-Torres, JE Orfila, OP Patsos… - Translational stroke …, 2020 - Springer
Hippocampal injury and cognitive impairments are common after cardiac arrest and stroke
and do not have an effective intervention despite much effort. Therefore, we developed a …

A new potential strategy for treatment of ischemic stroke: targeting TRPM2–NMDAR association

J Xu, W Zhang, J Dong, L Cao, Z Huang - Neuroscience Bulletin, 2023 - Springer
Accepted: 9 August 2022/Published online: 7 November 2022© Center for Excellence in
Brain Science and Intelligence Technology, Chinese Academy of Sciences 2022 astrocyte …

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

J Cheng, NJ Alkayed, PD Hurn - Journal of Cerebral Blood …, 2007 - journals.sagepub.com
Outcome from cerebral ischemia is sexually dimorphic in many experimental models. Male
animals display greater sensitivity to ischemic injury than do their female counterparts; …

[HTML][HTML] Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury

B Chen, G Ng, Y Gao, SW Low, E Sandanaraj… - Translational Stroke …, 2019 - Springer
The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a
key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel …