Chloride homeostasis determines the impact of inhibitory synaptic transmission and thereby
mediates the excitability of neurons. Even though cerebellar Purkinje cells (PCs) receive a …

As excitable cells, neurons experience constant changes in their membrane potential due to
ion flux through plasma membrane channels. They maintain their transmembrane cation …

Abstract The K+–Cl− co-transporter KCC2 (SLC12A5) tunes the efficacy of GABAA receptor-
mediated transmission by regulating the intraneuronal chloride concentration [Cl−] i. KCC2 …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Chloride (Cl−) homeostasis is critical for many cell functions including cell signaling and
volume regulation. The action of GABA at GABAA receptors is primarily determined by the …

Key points Cation–chloride cotransporters (CCCs) play a critical role in controlling the
efficacy and polarity of GABAA receptor (GABAAR)‐mediated transmission in the brain, yet …

In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …

The recent review by Doyon et al.(2016) is for the main part an excellent description of many
important aspects of neuronal chloride regulation and will be of good use to many scientists …

The intracellular chloride concentration [Cl−] i in neurons is regulated by a set of
transmembrane transporters, with the Cl−-loader NKCC1 and the Cl−-extruder KCC2 as …

The neuron‐specific potassium‐chloride cotransporter 2 (KCC2) plays a crucial role in
adjusting intracellular Cl− concentrations. The lack of KCC2 in the plasma membrane of the …