Although there is evidence that adult neurogenesis contributes to the therapeutic efficacy of
chronic antidepressant treatment for anxiety and depression disorders, the role of adult …

Understanding the reasons for the delayed action of antidepressants in patients with
depression is an important step in the effort to understand the etiology and course of this …

An emerging hypothesis, linking modulation of neurogenesis with the onset and subsequent
treatment of depression, has received much attention recently as an attractive explanation …

Major depressive disorder is a common debilitating mental health problem that represents
one of the leading causes of disability. Up to date, the therapeutic targets and approaches …

Hypotheses are scaffoldings erected in front of a building and then dismantled when the
building is finished. They are indispensable for the workman; but you mustn't mistake the …

Depression and anxiety involve hippocampal dysfunction, but the specific relationship
between these mood disorders and adult hippocampal dentate gyrus neurogenesis remains …

Adult neurogenesis has been implicated in affective disorders and the action of
antidepressants (ADs) although the functional significance of this association is still unclear …

Adult hippocampal neurogenesis is increased by antidepressants, and is required for some
of their behavioral effects. However, it remains unclear whether expanding the population of …

Highlights•Diverse animal models of depression and anxiety have impaired neurogenesis.•
Neurogenesis is consistently boosted by antidepressants in animal models when animals …

Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that
improve mood and alleviate anxiety. However, the underlying mechanisms remain largely …