Ethanol (EtOH) and nicotine are the most widely coabused drugs. Tolerance to EtOH
intoxication, including motor impairment, results in greater EtOH consumption and may …

Recent research suggests that adaptations elicited by drugs of abuse share common
features with traditional learning models, and that drugs of abuse cause long-term changes …

Recent research has suggested that the neuronal circuit adaptations elicited by drugs of
abuse share common features with traditional learning models, and that drugs of abuse …

Alcohol use disorder most commonly presents as a polydrug disorder where greater than
85% are estimated to smoke. EtOH and nicotine (NIC) co‐abuse or exposure results in …

The striatum is the largest input nucleus to the basal ganglia and associated with reward-
based behavior. We assessed whether acute ethanol (EtOH) exposure could modulate …

Alcohol use disorder is associated with altered neuron function including those in
orbitofrontal cortex (OFC) and basolateral amygdala (BLA) that send glutamatergic inputs to …

Background Increasing evidence suggests that chronic ethanol exposure decreases
dopamine (DA) neurotransmission in the nucleus accumbens (NAc), contributing to a …

Drug addictions including alcoholism are characterized by degradation of executive control
over behavior and increased compulsive drug seeking. These profound behavioral changes …

Although alcoholism is a worldwide problem resulting in millions of deaths, only a small
percentage of alcohol users become addicted. The specific neural substrates responsible for …

Glutamatergic synaptic plasticity in the nucleus accumbens (NAc) is implicated in response
to sensitization to psychomotor-stimulating agents, yet ethanol effects here are undefined …