CACNA1C: association with psychiatric disorders, behavior, and neurogenesis

AL Moon, N Haan, LS Wilkinson… - Schizophrenia …, 2018 - academic.oup.com
Large-scale genome-wide association studies have consistently shown that genetic
variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit …

Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

DP Prata, B Costa-Neves, G Cosme… - Journal of psychiatric …, 2019 - Elsevier
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function

S Hosseini, E Wilk, K Michaelsen-Preusse… - Journal of …, 2018 - Soc Neuroscience
Acute influenza infection has been reported to be associated with neurological symptoms.
However, the long-term consequences of an infection with neurotropic and non-neurotropic …

[HTML][HTML] Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood

N Dedic, ML Pöhlmann, JS Richter, D Mehta… - Molecular …, 2018 - nature.com
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …

[HTML][HTML] From gene to behavior: L-type calcium channel mechanisms underlying neuropsychiatric symptoms

ZD Kabir, A Martínez-Rivera, AM Rajadhyaksha - Neurotherapeutics, 2017 - Elsevier
The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition

E Vázquez-Rosa, MK Shin, M Dhar… - Proceedings of the …, 2020 - National Acad Sciences
Chronic neurodegeneration in survivors of traumatic brain injury (TBI) is a major cause of
morbidity, with no effective therapies to mitigate this progressive and debilitating form of …

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

ZD Kabir, A Che, DK Fischer, RC Rice, BK Rizzo… - Molecular …, 2017 - nature.com
CACNA1C, encoding the Ca v 1.2 subunit of L-type Ca 2+ channels, has emerged as one of
the most prominent and highly replicable susceptibility genes for several neuropsychiatric …

Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis

C Catavero, H Bao, J Song - Cell and tissue research, 2018 - Springer
Within the dentate gyrus of the adult hippocampus is the subgranular zone, which contains a
neurogenic niche for radial-glia like cells, the most primitive neural stem cells in the adult …

Application of P7C3 compounds to investigating and treating acute and chronic traumatic brain injury

PS Sridharan, E Miller, AA Pieper - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a leading worldwide cause of disability, and there are
currently no medicines that prevent, reduce, or reverse acute or chronic neurodegeneration …

[HTML][HTML] Methylome patterns of cattle adaptation to heat stress

M Del Corvo, B Lazzari, E Capra, L Zavarez… - Frontiers in …, 2021 - frontiersin.org
Heat stress has a detrimental impact on cattle health, welfare and productivity by affecting
gene expression, metabolism and immune response, but little is known on the epigenetic …