Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Highlights•Analysis using acute stimulation reveals that multiple signals are involved in
activity-dependent synapse growth or remodeling in Drosophila.•Addition of new synaptic …

In pleiotropic diseases, multiple organ systems are affected causing a variety of clinical
manifestations. Here, we report a pleiotropic disorder with a unique constellation of …

The kinesin-3 family member Unc-104/KIF1A is required for axonal transport of many
presynaptic components to synapses, and mutation of this gene results in synaptic …

Homeostatic matching of pre-and postsynaptic function has been observed in many species
and neural structures, but whether transcriptional changes contribute to this form of trans …

Mutations in the kinesin-3 family member KIF1A have been associated with hereditary
spastic paraplegia (HSP), hereditary and sensory autonomic neuropathy type 2 (HSAN2) …

Background Guanine nucleotide exchange factors (GEFs) play pivotal roles in neuronal cell
functions by exchanging GDP to GTP nucleotide and activation of GTPases. We aimed to …

The mechanisms underlying synaptic differentiation, which involves neuronal membrane
and cytoskeletal remodeling, are not completely understood. We performed a targeted RNAi …

This study provides further insight into the molecular mechanisms that control
neurotransmitter release. Experiments were performed on larval neuromuscular junctions of …

Positive and negative modes of regulation typically constrain synaptic growth and function
within narrow physiological ranges. However, it is unclear how synaptic strength is …