A prominent idea emerging from the study of sleep is that this key behavioural state is
regulated in a complex fashion by ecologically and physiologically relevant environmental …

Sleep is a biological enigma that has raised numerous questions about the inner workings
of the brain. The fundamental question of why our nervous systems have evolved to require …

The gut microbiome has been proposed to influence diverse behavioral traits of animals,
although the experimental evidence is limited and often contradictory. Here, we made use of …

The two‐process model of sleep regulation posits two main processes regulating sleep: the
circadian process controlled by the circadian clock and the homeostatic process that …

Recent studies have shown that gut microorganisms can modulate host lifespan and
activities, including sleep quality and motor performance. However, the role of gut microbial …

Molecular and circuit mechanisms for balancing competing drives are not well understood.
While circadian and homeostatic mechanisms generally ensure sufficient sleep at night …

Abstract Study Objectives Dysregulation of sleep is associated with metabolic diseases, and
metabolic rate (MR) is acutely regulated by sleep-wake behavior. In humans and rodent …

Abstract Autism Spectrum Disorder (ASD) is characterized by impaired social
communication, restricted interests, and repetitive and stereotyped behaviors. The TRPC6 …

The fruit fly, Drosophila melanogaster, has been used as a model organism for the
molecular and genetic dissection of sleeping behaviors. However, most previous studies …

Age-specific and diurnal patterns of locomotory activity, can be considered as biomarkers of
aging in model organisms and vary across the lifetime of individuals. Τhe Mediterranean fruit …