[HTML][HTML] Progress in gene therapy to prevent retinal ganglion cell loss in glaucoma and Leber's hereditary optic neuropathy
SE Ratican, A Osborne, KR Martin - Neural plasticity, 2018 - hindawi.com
The eye is at the forefront of the application of gene therapy techniques to medicine. In the
United States, a gene therapy treatment for Leber's congenital amaurosis, a rare inherited …
United States, a gene therapy treatment for Leber's congenital amaurosis, a rare inherited …
[HTML][HTML] Interactions between guidance cues and neuronal activity: therapeutic insights from mouse models
Topographic mapping of neural circuits is fundamental in shaping the structural and
functional organization of brain regions. This developmentally important process is crucial …
functional organization of brain regions. This developmentally important process is crucial …
Differentiation of retinal organoids from human pluripotent stem cells
Human pluripotent stem cells (hPSCs) possess the remarkable ability to differentiate into
any cell type of the body, including those of the retina. Through the differentiation of these …
any cell type of the body, including those of the retina. Through the differentiation of these …
[HTML][HTML] Age Related Response of Neonatal Rat Retinal Ganglion Cells to Reduced TrkB Signaling in vitro and in vivo
J Beros, J Rodger, AR Harvey - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
During development of retinofugal pathways there is naturally occurring cell death of at least
50% of retinal ganglion cells (RGCs). In rats, RGC death occurs over a protracted pre-and …
50% of retinal ganglion cells (RGCs). In rats, RGC death occurs over a protracted pre-and …
Developmental retinal ganglion cell death and retinotopicity of the murine retinocollicular projection
J Beros, J Rodger, AR Harvey - Developmental Neurobiology, 2018 - Wiley Online Library
During mammalian visual system development, retinal ganglion cells (RGCs) undergo
extensive apoptotic death. In mouse retina, approximately 50% of RGCs present at birth …
extensive apoptotic death. In mouse retina, approximately 50% of RGCs present at birth …
Constructing multilayered neural networks with sparse, data-driven connectivity using biologically-inspired, complementary, homeostatic mechanisms
RA Baxter, WB Levy - Neural Networks, 2020 - Elsevier
The immense complexity of the brain requires that it be built and controlled by intrinsic, self-
regulating mechanisms. One such mechanism, the formation of new connections via …
regulating mechanisms. One such mechanism, the formation of new connections via …
[BOOK][B] Axonal Outgrowth and Pathfinding of Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells
CM Fligor - 2020 - search.proquest.com
Retinal ganglion cells (RGCs) serve as a vital connection between the eye and the brain
with damage to their axons resulting in loss of vision and/or blindness. Retinal organoids are …
with damage to their axons resulting in loss of vision and/or blindness. Retinal organoids are …