[HTML][HTML] The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease

L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

[HTML][HTML] The complex interactions between obesity, metabolism and the brain

RM Uranga, JN Keller - Frontiers in neuroscience, 2019 - frontiersin.org
Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on
the various organ systems of the body is only beginning to be fully appreciated. Because of …

[HTML][HTML] Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies

ME Casado, R Collado-Pérez, LM Frago… - International Journal of …, 2023 - mdpi.com
Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

[HTML][HTML] Regulation of hippocampal synaptic function by the metabolic hormone, leptin: implications for health and neurodegenerative disease

G McGregor, J Harvey - Frontiers in cellular neuroscience, 2018 - frontiersin.org
The role of the endocrine hormone leptin in controlling energy homeostasis in the
hypothalamus are well documented. However the CNS targets for leptin are not restricted to …

[HTML][HTML] Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease

ML Calió, AC Mosini, DS Marinho, GN Salles… - Neurobiology of …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common dementia worldwide and is characterized by
the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of …

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

LM Riggs, Y Aracava, P Zanos, J Fischell… - …, 2020 - nature.com
Preclinical studies indicate that (2R, 6R)-hydroxynorketamine (HNK) retains the rapid and
sustained antidepressant-like actions of ketamine, but is spared its dissociative-like …

Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease

A Irving, J Harvey - Progress in Lipid Research, 2021 - Elsevier
Significant advances have been made in our understanding of the hormone, leptin and its
CNS actions in recent years. It is now evident that leptin has a multitude of brain functions …

[HTML][HTML] The neuronal actions of leptin and the implications for treating Alzheimer's disease

K Hamilton, J Harvey - Pharmaceuticals, 2021 - mdpi.com
It is widely accepted that the endocrine hormone leptin controls food intake and energy
homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons …

Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research

THY Lee, DA Formolo, T Kong, SWY Lau… - International review of …, 2019 - Elsevier
A sedentary lifestyle is now known as a critical risk factor for accelerated aging-related
neurodegenerative disorders. In contract, having regular physical exercise has opposite …

Synaptic plasticity modulation by circulating peptides and metaplasticity: involvement in Alzheimer's disease

S Peineau, K Rabiant, O Pierrefiche, B Potier - Pharmacological Research, 2018 - Elsevier
Synaptic plasticity is a cellular process involved in learning and memory whose alteration in
its two main forms (Long Term Depression (LTD) and Long Term Potentiation (LTP)), is …