User profiles for S. Gorur-Shandilya

Srinivas Gorur-Shandilya

Yale University
Verified email at yale.edu
Cited by 709

[HTML][HTML] The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors

…, S Gorur-Shandilya, K Menuz, NK Larter, S Stewart… - Neuron, 2014 - cell.com
Insects use taste to evaluate food, hosts, and mates. Drosophila has many "orphan" taste
neurons that express no known taste receptors. The Ionotropic Receptor (IR) superfamily is

Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

S Gorur-Shandilya, M Demir, J Long, DA Clark… - Elife, 2017 - elifesciences.org
… to the brain, so the timing of an odor whiff is accurately captured regardless of how strong
it is. Based on these results, Gorur-Shandilya et al. created a biophysical model that could …

[PDF][PDF] MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration

…, LY Ng, CYY Chong, YT Ng, S Gorur-Shandilya… - Cell Reports, 2022 - cell.com
… In summary, sima/Hif is induced in response to SNCA expression and is required cell
autonomously for neuroprotection. Furthermore, DFO upregulates Sima/Hif in fly brains and sup…

Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

D Powell, SA Haddad, S Gorur-Shandilya, E Marder - Elife, 2021 - elifesciences.org
Coupled oscillatory circuits are ubiquitous in nervous systems. Given that most biological
processes are temperature-sensitive, it is remarkable that the neuronal circuits of …

Mapping circuit dynamics during function and dysfunction

S Gorur-Shandilya, EM Cronin, AC Schneider… - Elife, 2022 - elifesciences.org
… The anterior burster (AB) neuron is an endogenous burster and is electrically coupled to
PD neurons. (b) When the stn is cut, neuromodulatory input is removed and the circuit is ‘…

[HTML][HTML] Activity-dependent compensation of cell size is vulnerable to targeted deletion of ion channels

S Gorur-Shandilya, E Marder, T O'Leary - Scientific reports, 2020 - nature.com
… The mechanism we put forward is a parsimonious way to achieve this that is also compatible
with … A mechanism that is tuned specifically to deal with these perturbations is necessarily …

Controlling and measuring dynamic odorant stimuli in the laboratory

S Gorur-Shandilya, C Martelli… - Journal of …, 2019 - journals.biologists.com
… To fully account for these effects, a model that considers the spatio-temporal dynamics of
odor concentration along and across the tubes is needed, but is beyond the scope of this paper…

Presynaptic GABA receptors mediate temporal contrast enhancement in Drosophila olfactory sensory neurons and modulate odor-driven behavioral kinetics

D Raccuglia, LY McCurdy, M Demir, S Gorur-Shandilya… - Eneuro, 2016 - eneuro.org
Contrast enhancement mediated by lateral inhibition within the nervous system enhances
the detection of salient features of visual and auditory stimuli, such as spatial and temporal …

Inferring network topology from complex dynamics

SG Shandilya, M Timme - New Journal of Physics, 2011 - iopscience.iop.org
Inferring the network topology from dynamical observations is a fundamental problem pervading
research on complex systems. Here, we present a simple, direct method for inferring the …

Regulation of Eag by Ca2+/calmodulin controls presynaptic excitability in Drosophila

…, EA Kuklin, S Gorur-Shandilya… - Journal of …, 2018 - journals.physiology.org
… Such a channel would be predicted to pass more current when Ca 2+ concentration is
high. In this study we show that fly EAG is inhibited by Ca 2+ /CaM, and we generate mutant …