Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and
neurodegenerative diseases are essential for increasing our understanding of underlying …

Alzheimer’s disease (AD) is a progressive neurodegenerative disease resulting in cognitive
decline. A unique rat model, TgF344-AD, recapitulates pathological hallmarks of AD. We …

… Data were analyzed by means of a mixed model repeated measures (RM) ANOVA. The
between subjects’ variable was genotype. The within subjects’ variables were day and phase (…

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is also
highly associated with autism spectrum disorders (ASD). It is caused by expansion of a CGG …

… Michelle Saré a , Merlin Levine a , Christine Hildreth a , Dante Picchioni a b , Carolyn …
Michelle Reith (Saré), and a summer fellowship from the Irene & Eric Simon Brain Research …

Sleep problems are prevalent in people with autism spectrum disorder (ASD). Several
studies have shown an association between sleep problems and severity of ASD‐related …

SHANK3 is a postsynaptic scaffolding protein that plays a critical role in synaptic development
and brain function. Mutations in SHANK3 are implicated in Phelan-McDermid syndrome (…

Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is
thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. …

Fragile X syndrome (FXS) is the most commonly inherited form of intellectual disability and is
a disorder that is also highly associated with autism. FXS occurs as a result of an expanded …

Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene leading to loss of the
protein product fragile X mental retardation protein (FMRP). FXS is the most common …