User profiles for R. L. Medcalf

Robert L. Medcalf

Monash University
Verified email at monash.edu
Cited by 8627

[HTML][HTML] Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity

AL Samson, RL Medcalf - Neuron, 2006 - cell.com
For over a decade, tissue-type plasminogen activator (t-PA), a serine protease classically
known for its profibrinolytic role in the vasculature, has been implicated in numerous aspects of …

Haemostasis and innate immunity–a complementary relationship: a review of the intricate relationship between coagulation and complement pathways

…, DF Draxler, ZK McQuilten, RL Medcalf - British journal of …, 2018 - Wiley Online Library
Coagulation and innate immunity are linked evolutionary processes that orchestrate the
host defence against invading pathogens and injury. The complement system is integral to …

Plasminogen: an enigmatic zymogen

CB Keragala, RL Medcalf - Blood, The Journal of the American …, 2021 - ashpublications.org
Plasminogen is an abundant plasma protein that exists in various zymogenic forms. Plasmin,
the proteolytically active form of plasminogen, is known for its essential role in fibrinolysis. …

[HTML][HTML] Fibrinolysis and COVID‐19: a plasmin paradox

RL Medcalf, CB Keragala, PS Myles - Journal of Thrombosis and …, 2020 - Elsevier
… Robert L Medcalf is supported by research grants awarded by The National Health and
Medical Research Council (NHMRC) of Australia, grant ID 1045755 and 1156506. Charithani B. …

Fibrinolysis, inflammation, and regulation of the plasminogen activating system

RL Medcalf - Journal of Thrombosis and Haemostasis, 2007 - Wiley Online Library
… 70 Maurer F, Medcalf RL. Plasminogen activator inhibitor type 2 gene induction by tumor
necrosis factor and phorbol ester involves transcriptional and post-transcriptional events. …

Reduced phosphoinositide 3-kinase (p110α) activation increases the susceptibility to atrial fibrillation

…, H Kiriazis, RCY Lin, S Marasco, RL Medcalf… - The American journal of …, 2009 - Elsevier
Atrial fibrillation (AF) is the most common sustained arrhythmia presenting at cardiology
departments. A limited understanding of the molecular mechanisms responsible for the …

Vampire bat salivary plasminogen activator (desmoteplase) a unique fibrinolytic enzyme that does not promote neurodegeneration

…, A Samson, C Bladin, WD Schleuning, RL Medcalf - Stroke, 2003 - Am Heart Assoc
… This study was funded by grants awarded to Dr Medcalf from the National Health and
Medical Research Council of Australia; by the Department of Neurosciences, Box Hill Hospital, …

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

…, R Stuchbery, SJ Liu, M Sashindranath, RL Medcalf… - Brain, 2015 - academic.oup.com
Traumatic brain injury is a common and serious neurodegenerative condition that lacks a
pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is …

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

M Zimmer, RL Medcalf, TM Fink… - Proceedings of the …, 1992 - National Acad Sciences
The human neutrophil and monocyte-derived serine protease homologues neutrophil
elastase (NE), proteinase 3 (PR3), and azurocidin (AZU) are involved in a variety of immune …

The undecided serpin: the ins and outs of plasminogen activator inhibitor type 2

RL Medcalf, SJ Stasinopoulos - The FEBS journal, 2005 - Wiley Online Library
Plasminogen activator inhibitor type‐2 (PAI‐2) is a nonconventional serine protease
inhibitor (serpin) with unique and tantalizing properties that is generally considered to be an …