A widely held dogma in the preclinical addiction field is that females are more vulnerable than
males to drug craving and relapse. Here, we first review clinical studies on sex differences …

The Cannabis sativa plant has been used to treat various physiological and psychiatric
conditions for millennia. Current research is focused on isolating potentially therapeutic chemical …

The endocannabinoid (eCB) system has emerged as one of the most important mediators of
physiological and pathological reward-related synaptic plasticity. eCBs are retrograde …

In comparison to men, women initiate drug use at earlier ages and progress from initial use
to addiction more rapidly. This heightened intake and vulnerability to drugs of abuse is …

Rationale and objectives Previous work has shown that wheel running reduced the maintenance
of cocaine self-administration in rats. In the present study, the effect of wheel running …

… as previously described (Zlebnik et al. 2010; Zlebnik et al. 2012). Data collection and
programming were conducted using PC computers with a Med-PC interface (MedAssociates, Inc.). …

Impulsive choice has enduring trait-like characteristics and is defined by preference for small
immediate rewards over larger delayed ones. Importantly, it is a determining factor in the …

Background Individually, both treatment with progesterone and concurrent access to an
exercise wheel reduce cocaine self-administration under long-access conditions and suppress …

… Thomas Baron and Natalie Zlebnik were involved in data analysis, graphic presentation, and
manuscript preparation. All authors were involved in the final preparation of the manuscript, …

Rationale Concurrent access to an exercise wheel decreases cocaine self-administration
under short access (5 h/day for 5 days) conditions and suppresses cocaine-primed …