Cognitive deficits and associated neurological complications in individuals with Down's syndrome

IT Lott, M Dierssen - The Lancet Neurology, 2010 - thelancet.com
Improvements in medical interventions for people with Down's syndrome have led to a
substantial increase in their longevity. Diagnosis and treatment of neurological complications are …

Down syndrome: the brain in trisomic mode

M Dierssen - Nature Reviews Neuroscience, 2012 - nature.com
Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study …

[HTML][HTML] Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

…, L Xicota, M Fitó, M Farré, M Dierssen… - Molecules, 2015 - mdpi.com
… JR-M. was supported by a FI-DGR2012 predoctoral fellowship from the Generalitat de
Catalunya. … Montse Fitó, Magí Farré and Mara Dierssen critically revised the manuscript. …

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

X Altafaj, M Dierssen, C Baamonde… - Human molecular …, 2001 - academic.oup.com
Down’s syndrome (DS) is a major cause of mental retardation, hypotonia and delayed
development. Murine models of DS carrying large murine or human genomic fragments show …

Epigallocatechin‐3‐gallate, a DYRK1A inhibitor, rescues cognitive deficits in D own syndrome mouse models and in humans

…, Y Herault, JM Delabar, M Dierssen - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Trisomy for human chromosome 21 results in D own syndrome ( DS ), which is among
the most complex genetic perturbations leading to intellectual disability. Accumulating data …

Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

V Fotaki, M Dierssen, S Alcántara… - … and cellular biology, 2002 - Taylor & Francis
… Guimerà for valuable advice during the initial design of the project, the staff of the animal
facility, M. Ródenas for technical contributions to the histology of the mouse embryos, M. …

[PDF][PDF] Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes

…, G Ciceri, MV Gabaldón, D Moratal, M Dierssen… - Neuron, 2013 - cell.com
Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia,
although little is known about how they contribute to the disease process. Here, we have …

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo …

…, S Videla, M Fitó, JM Delabar, M Dierssen - The Lancet …, 2016 - thelancet.com
Background Early cognitive intervention is the only routine therapeutic approach used for
amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are …

Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway

…, R Gherardi, C Christov, M Dierssen… - Genes & …, 2008 - genesdev.cshlp.org
In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively
replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic …

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model

…, IF Vallina, C Baamonde, MA Lumbreras, M Dierssen… - Neuroscience …, 1995 - Elsevier
Mice which are trisomic for only the human chromosome (Chr) 21-homologous segment of
mouse Chr 16 (segmental trisomy), including a portion of the Down syndrome region of …