Rationale This review provides insight for the judicious selection of nicotine dose ranges and
routes of administration for in vivo studies. The literature is replete with reports in which a …

Nicotinic acetylcholine receptors (nACh receptors2) in jawed vertebrates are prototypical
members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic …

… with functional differences ([111] and MJ Marks, unpublished data); however, these two
forms may have similar binding affinities (MJ Marks, unpublished data). These properties of …

The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects
of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits …

… In marked contrast to the absence of hybridization of old-probe observed in cerebellum,
the hybridization intensity for the &-probe in the granule cell layer of the cerebellum was very …

… There was a marked increase in nicotine consumption across the dose–response curve
in the Lenti-α5-shRNA rats that was most apparent at high unit doses (Fig. 3a). When total …

Chronic nicotine administration in animal models evokes a dose-dependent increase in brain
nicotinic receptor numbers. Genetically determined variability in nicotinic receptor number …

Previous studies have suggested that an abnormality in neuronal nicotinic acetylcholine
receptor expression or function may be involved in the neuropathophysiology of schizophrenia. …

… The last two decades marked the emergence of the Asian epoxy industry. In the 1980s,
the Japanese epoxy industry was transformed from a number of joint venture companies with …

Pharmacological evaluation of nicotine-stimulated dopamine release from striatum has yielded
data consistent with activation of a single population of nicotinic acetylcholine receptors (…