[HTML][HTML] Extracellular vesicles: biomarkers, therapeutics, and vehicles in the visual system

Y van der Merwe, MB Steketee - Current Ophthalmology Reports, 2017 - Springer
Purpose We discuss recent advances in extracellular vesicle (EV) technology as biomarkers,
therapeutics, and drug delivery vehicles in the visual system with an emphasis on the retina…

Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth

MB Steketee, SN Moysidis, XL Jin… - Proceedings of the …, 2011 - National Acad Sciences
Understanding neurite growth regulation remains a seminal problem in neurobiology.
During development and regeneration, neurite growth is modulated by neurotrophin-activated …

Three functionally distinct adhesions in filopodia: shaft adhesions control lamellar extension

MB Steketee, KW Tosney - Journal of Neuroscience, 2002 - Soc Neuroscience
In this study, adhesions on individual filopodial shafts were shown to control veil (lamellar)
advance and to be modulated by guidance cues. Adhesions were detected in individual …

[HTML][HTML] Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function

…, IP Conner, VLN Fu, SF Badylak, MB Steketee - Scientific reports, 2019 - nature.com
Injury to retinal ganglion cells (RGC), central nervous system neurons that relay visual
information to the brain, often leads to RGC axon degeneration and permanently lost visual …

[HTML][HTML] Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro

MB Steketee, SN Moysidis… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Retinal ganglion cell (RGC) death and failed axonal regeneration after trauma or
disease, including glaucomatous and mitochondrial optic neuropathies, are linked …

[HTML][HTML] Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones

MB Steketee, C Oboudiyat, R Daneman… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: Mammalian central nervous system neurons fail to regenerate after injury or disease,
in part due to a progressive loss in intrinsic axon growth ability after birth. Whether lost …

Promoting filopodial elongation in neurons by membrane-bound magnetic nanoparticles

W Pita-Thomas, MB Steketee, SN Moysidis… - … , Biology and Medicine, 2015 - Elsevier
Steketee PhD a c , Stavros N. Moysidis MD a , Kinjal Thakor a , Blake Hampton BS a ,
Jeffrey L. Goldberg MD PhD a d … MB Steketee, KW Tosney … MB Steketee, KW Tosney …

Developing extracellular matrix technology to treat retinal or optic nerve injury

T Ren, Y van der Merwe, MB Steketee - ENeuro, 2015 - eneuro.org
Adult mammalian CNS neurons often degenerate after injury, leading to lost neurologic
functions. In the visual system, retinal or optic nerve injury often leads to retinal ganglion cell …

[HTML][HTML] Fetal extracellular matrix nerve wraps locally improve peripheral nerve remodeling after complete transection and direct repair in rat

…, SF Badylak, KM Washington, MB Steketee - Scientific reports, 2018 - nature.com
In peripheral nerve (PN) injuries requiring surgical repair, as in PN transection, cellular and
ECM remodeling at PN epineurial repair sites is hypothesized to reduce PN functional …

[HTML][HTML] Matrix bound vesicles and miRNA cargoes are bioactive factors within extracellular matrix bioscaffolds

…, AE Faust, MB Steketee - Neural regeneration …, 2017 - journals.lww.com
… Ren T, van der Merwe Y, Steketee MB. Developing extracellular matrix technology to treat
… van der Merwe Y, Steketee MB. Immunomodulatory approaches to CNS injury: extracellular …