… Tellez and IE de Araujo, unpublished observations). Such deficits are therefore consistent
with the observed diminishing in motivation to eat upon disruption of striatal dopamine …

The gut is now recognized as a major regulator of motivational and emotional states.
However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical …

Excessive intake of dietary fats leads to diminished brain dopaminergic function. It has been
proposed that dopamine deficiency exacerbates obesity by provoking compensatory …

Superior predatory skills led to the evolutionary triumph of jawed vertebrates. However, the
mechanisms by which the vertebrate brain controls predation remain largely unknown. Here, …

Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It
is, however, unknown whether sweetness and nutritional signals engage segregated brain …

It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators
of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either …

10.7554/eLife.01462.001 Sugars that contain glucose, such as sucrose, are generally
preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates …

Bariatric surgery remains the single most effective long-term treatment modality for morbid
obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. …

Key points • The hedonic orosensory properties of fats strongly promote intake, but it remains
unknown whether fat intake stimulates brain reward circuits in the absence of orosensory …

Reductions in calorie intake contribute significantly to the positive outcome of bariatric
surgeries. However, the physiological mechanisms linking the rerouting of the gastrointestinal …