[HTML][HTML] Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases …

K Maeta, S Hattori, J Ikutomo, H Edamatsu, SE Bilasy… - Molecular brain, 2018 - Springer
… Mice used in this study had been backcrossed over 11 times to the C57BL/6 J strain.
Rapgef2-cKO (Rapgef2 flox/flox ;Emx1 cre/+ ) mice were prepared by mating Rapgef2 flox/flox mice …

Crucial role of Rapgef2 and Rapgef6, a family of guanine nucleotide exchange factors for Rap1 small GTPase, in formation of apical surface adherens junctions and …

K Maeta, H Edamatsu, K Nishihara, J Ikutomo… - Eneuro, 2016 - eneuro.org
Cerebral neocortex development in mammals requires highly orchestrated events involving
proliferation, differentiation, and migration of neural progenitors and neurons. Rapgef2 and …

Gait abnormality predicts falls in women after total hip arthroplasty

H Ikutomo, K Nagai, K Tagomori, N Miura… - The Journal of …, 2018 - Elsevier
Background Patients who undergo total hip arthroplasty (THA) have an increased risk of falls
during the first year postoperatively. However, risk factors for falls after THA remain unclear. …

Fear of falling during activities of daily living after total hip arthroplasty in Japanese women: a cross-sectional study

K Nagai, H Ikutomo, M Yamada, T Tsuboyama… - Physiotherapy, 2014 - Elsevier
Objectives To investigate the prevalence of fear of falling, and identify factors associated with
fear of falling during activities of daily living after total hip arthroplasty (THA). Design Cross-…

Effect of streptozotocin-induced diabetes on motor representations in the motor cortex and corticospinal tract in rats

K Muramatsu, M Ikutomo, T Tamaki, S Shimo, M Niwa - Brain research, 2018 - Elsevier
… I–J: Comparisons of the control and diabetic animals for average number (I) and mean cross…
I–J: Comparisons of the control and diabetic animals for average number (I) and mean cross-…

Motor skills training-induced activation of descending pathways mediating cortical command to hindlimb motoneurons in experimental diabetic rats

K Muramatsu, N Niimi, M Ikutomo, S Shimo… - Experimental …, 2023 - Elsevier
Diabetes disrupts the corticospinal tract (CST) system components that control hindlimb and
trunk movement, resulting in weakness of the lower extremities. However, there is no …

Midkine-deficient mice delayed degeneration and regeneration after skeletal muscle injury

M Ikutomo, H Sakakima, F Matsuda, Y Yoshida - Acta histochemica, 2014 - Elsevier
Midkine (MK), a heparin-binding growth factor, was previously found to be expressed in the
rat myotube-forming stage. We investigated MK gene-deficient (Mdk −/− ) mice in terms of …

Effect of streptozotocin-induced diabetes on motoneurons and muscle spindles in rats

K Muramatsu, M Niwa, T Tamaki, M Ikutomo… - Neuroscience …, 2017 - Elsevier
This study examined the alterations in the number and size of motoneurons innervating the
medial gastrocnemius (MG) and biceps femoris (BF) motor nuclei in diabetic rats (12 or 22 …

Incidence and circumstances of falls in women before and after total hip arthroplasty: a prospective cohort study

H Ikutomo, K Nagai, K Tagomori, N Miura… - The Journal of …, 2018 - Elsevier
Background We investigated the incidence and circumstances related to falls in patients
before and after total hip arthroplasty (THA), and compared them with those in an age-matched …

Asymmetrical loading during sit-to-stand movement in patients 1 year after total hip arthroplasty

N Miura, K Tagomori, H Ikutomo, N Nakagawa… - Clinical …, 2018 - Elsevier
Background Asymmetrical loading during functional performance can occur after total hip
arthroplasty. We hypothesized that during sit-to-stand movements, the loading of the limbs of …