[HTML][HTML] The past, present and future of stem cell clinical trials for ALS

GM Thomsen, G Gowing, S Svendsen… - Experimental …, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is
characterized by progressive degeneration of motor neurons in the cortex, brainstem and spinal …

Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex

GM Thomsen, G Gowing, J Latter, M Chen… - Journal of …, 2014 - Soc Neuroscience
Sporadic amyotrophic lateral sclerosis (ALS) is a fatal disease with unknown etiology,
characterized by a progressive loss of motor neurons leading to paralysis and death typically …

First Detection of TR46/Y121F/T289A and TR34/L98H Alterations in Aspergillus fumigatus Isolates from Azole-Naive Patients in Denmark despite Negative Findings …

…, TM Hassan, EG Mathiasen, GM Thomsen… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Azole-resistant Aspergillus fumigatus harboring the TR 34 /L98H or TR 46 /Y121F/T289A
alterations is increasingly found in Europe and Asia. Here, we present the first clinical cases of …

Transplantation of neural progenitor cells expressing glial cell line-derived neurotrophic factor into the motor cortex as a strategy to treat amyotrophic lateral sclerosis

GM Thomsen, P Avalos, AA Ma, M Alkaslasi, N Cho… - Stem Cells, 2018 - academic.oup.com
Early dysfunction of cortical motor neurons may underlie the initiation of amyotrophic lateral
sclerosis (ALS). As such, the cortex represents a critical area of ALS research and a …

Dopamine neuron dependent behaviors mediated by glutamate cotransmission

S Mingote, N Chuhma, A Kalmbach, GM Thomsen… - Elife, 2017 - elifesciences.org
10.7554/eLife.27566.001 Dopamine neurons in the ventral tegmental area use glutamate
as a cotransmitter. To elucidate the behavioral role of the cotransmission, we targeted the …

Early propranolol after traumatic brain injury is associated with lower mortality

…, MY Harada, G Barmparas, GM Thomsen… - Journal of Trauma …, 2016 - journals.lww.com
BACKGROUND β-Adrenergic receptor blockers (BBs) administered after trauma blunt the
cascade of immune and inflammatory changes associated with injury. BBs are associated with …

[HTML][HTML] 10-Year trend in crystalloid resuscitation: reduced volume and lower mortality

…, EJT Smith, BK Patel, NK Dhillon, GM Thomsen… - International Journal of …, 2017 - Elsevier
Background Liberal emergency department (ED) resuscitation after trauma may lead to
uncontrolled hemorrhage, reduced organ perfusion, and compartment syndrome. Recent …

[HTML][HTML] Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects

GM Thomsen, M Alkaslasi, JP Vit, G Lawless, M Godoy… - Gene therapy, 2017 - nature.com
Injecting proteins into the central nervous system that stimulate neuronal growth can lead to
beneficial effects in animal models of disease. In particular, glial cell line-derived …

A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype

GM Thomsen, AM Ma, A Ko, MY Harada… - Journal of trauma and …, 2016 - journals.lww.com
… In this important study by Thomsen and colleagues, the authors developed a model which
may have moved us a bit closer to clinical relevance. In contrast to many other TBI models, …

[HTML][HTML] Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

…, J Masson, C Gellman, GM Thomsen… - Frontiers in systems …, 2016 - frontiersin.org
… The genetic intervention achieves perfect target specificity, with the only off-target effects
being those of Tmx, which are controlled for by treating both control and genetically modified