User profiles for D. C. Sloas

David Christopher Sloas

Carisma Therapeutics
Verified email at carismatx.com
Cited by 278

Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection

DC Sloas, JC Tran, AM Marzilli, JT Ngo - Nature biotechnology, 2023 - nature.com
Cells interpret mechanical stimuli from their environments and neighbors, but the ability to
engineer customized mechanosensing capabilities has remained a synthetic and …

VEGF‐C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model

RS Sweat, DC Sloas, WL Murfee - Microcirculation, 2014 - Wiley Online Library
Objective Lymphatic and blood microvascular systems are critical for tissue function. Insights
into the coordination of both systems can be gained by investigating the relationships …

Chemogenetic control of gene expression and cell signaling with antiviral drugs

EP Tague, HL Dotson, SN Tunney, DC Sloas, JT Ngo - Nature methods, 2018 - nature.com
We developed a method in which the NS3 cis-protease from hepatitis C virus can be used
as a ligand-inducible connection to control the function and localization of engineered …

Estimation of the pressure drop required for lymph flow through initial lymphatic networks

DC Sloas, SA Stewart, RS Sweat… - … research and biology, 2016 - liebertpub.com
Background: Lymphatic function is critical for maintaining interstitial fluid balance and is
linked to multiple pathological conditions. While smooth muscle contractile mechanisms …

Aging is associated with impaired angiogenesis, but normal microvascular network structure, in the rat mesentery

RS Sweat, DC Sloas, SA Stewart… - American Journal …, 2017 - journals.physiology.org
A big problem associated with aging is thought to be impaired microvascular growth or
angiogenesis. However, to link the evidence for impaired angiogenesis to microvascular …

Interactions across multiple stimulus dimensions in primary auditory cortex

DC Sloas, R Zhuo, H Xue, AR Chambers, E Kolaczyk… - Eneuro, 2016 - eneuro.org
Although sensory cortex is thought to be important for the perception of complex objects, its
specific role in representing complex stimuli remains unknown. Complex objects are rich in …

Tension-Tuned SynNotch Receptors for Synthetic Mechanotranduction and Intercellular Force Detection

DC Sloas, JC Tran, AM Marzilli, JT Ngo - bioRxiv, 2022 - biorxiv.org
Cells can sense and interpret mechanical stimuli from their environments and neighbors, but
the ability to engineer customized mechanosensing capabilities has remained a synthetic …

Engineering mechanotransduction in mammalian cells using the Notch receptor

DC Sloas - 2020 - search.proquest.com
Mechanical forces are fundamental regulators of biology. Individual cells can detect
environmental forces and transform them into intracellular biochemical actions, which impact gene …

[PDF][PDF] Synthetic Mechanotransduction Using Engineered SynNotch Receptors

DC Sloas, JT Ngo - scholar.archive.org
Cells can sense and interpret mechanical stimuli from their environment, but the ability to
engineer customized mechanosensing capabilities has remained a synthetic biology challenge…

[HTML][HTML] Small Vessels-Big Problems: Novel Insights into Microvascular Mechanisms of Diseases: Aging is associated with impaired angiogenesis, but normal …

RS Sweat, DC Sloas, SA Stewart… - American Journal of …, 2017 - ncbi.nlm.nih.gov
A big problem associated with aging is thought to be impaired microvascular growth or
angiogenesis. However, to link the evidence for impaired angiogenesis to microvascular …