Compounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal
cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or …

… GABAB(1)+/− Balb/c ES cells were injected into C57BL/6 blastocysts and chimeric males
were crossed with Balb/c females. This resulted in an F1 generation of inbred Balb/c GABAB(1)…

Addictive drugs have in common that they target the mesocorticolimbic dopamine (DA)
system. This system originates in the ventral tegmental area (VTA) and projects mainly to the …

… (C) Bidirectional change in CA3-CA1 synaptic efficacy by LTD and LTP in the same synapses
monitored by … Note the contrasting induction protocols (Data from C Lüscher, unpubl.). …

Drugs of abuse induce long-lasting changes in neural circuits that may underlie core components
of addiction. Here we focus on glutamatergic synapses onto dopamine (DA) neurons …

To study the role of G protein-coupled, inwardly rectifying K + (GIRK) channels in mediating
neurotransmitter actions in hippocampal neurons, we have examined slices from transgenic …

Little is known about the mechanisms that regulate the number of ionotropic glutamate
receptors present at excitatory synapses. Herein, we show that GluR1-containing α-amino-3-…

The biochemical composition of the postsynaptic membrane and the structure of dendritic
spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss …

Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral
tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism …

… c, Bar graphs representing group data for the rectification index. F (2,19) = 28.97; n = 6–8.
Data … We thank members of the Lüscher laboratory as well as M. Frerking, M. Serafin and H. …