Microglia are the resident macrophages of the CNS, and their functions have been
extensively studied in various brain pathologies. The physiological roles of microglia in brain …

Neurotrophins are growth factors that promote cell survival, differentiation, and cell death.
They are synthesized as proforms that can be cleaved intracellularly to release mature, …

The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine
kinase (p140 prototrk ) that is expressed only in neural tissues. Nerve growth factor (NGF) …

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF)
gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated …

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be
distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and …

Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …

Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …

Sortilin 1 (∼95 kDa) is a member of the recently discovered family of Vps10p-domain receptors
2 , 3 , and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It …

The neurotrophin family of survival factors is distinguished by a unique receptor-signaling
system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), …

Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and
cardiovascular development and function. Recently, a common single nucleotide polymorphism in …