User profiles for A. S. Lee

Allen S. Lee

Professor Emeritus of Information Systems, Virginia Commonwealth University
Verified email at alum.mit.edu
Cited by 15723

Stress induction of GRP78/BiP and its role in cancer

J Li, AS Lee - Current molecular medicine, 2006 - ingentaconnect.com
… may exist as a cell surface transmembrane protein as well. Recently, it has been reported
that MTJ-1, which is itself a transmembrane protein, associates with GRP78 in the ER as a co-…

GRP78 induction in cancer: therapeutic and prognostic implications

AS Lee - Cancer research, 2007 - AACR
… Autoantibody levels against GRP78 in patient serum, as well as expression levels of GRP78
in biopsies, may represent novel biomarkers in stratifying patients for tumor behavior and …

[HTML][HTML] Methicillin-resistant Staphylococcus aureus

AS Lee, H De Lencastre, J Garau… - Nature reviews Disease …, 2018 - nature.com
… aureus has the remarkable ability to acquire resistance to any antibiotic 7 , which has
major implications for current as well as future treatment options for this pathogen. …

A scientific methodology for MIS case studies

AS Lee - MIS quarterly, 1989 - JSTOR
… of the system will reduce resistance as long as the conditions which gave rise to it persist.
[The prediction is that there will be resistance as long as there are] mismatches between the …

[HTML][HTML] Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

J Li, B Lee, AS Lee - Journal of Biological Chemistry, 2006 - ASBMB
… /EBP homologous protein (CHOP) and caspase-12, as their activation is intact in p53 -/- MEFs.
In … Reversibly, overexpression of NOXA or PUMA induces apoptosis as evidenced by the …

Diet and the evolution of human amylase gene copy number variation

GH Perry, NJ Dominy, KG Claw, AS Lee, H Fiegler… - Nature …, 2007 - nature.com
as in our study. For the Yakut aCGH experiments, we used the same reference DNA sample
(NA10851) as … because microsatellite loci are usually multiallelic (as is the AMY1 locus). We …

Integrating positivist and interpretive approaches to organizational research

AS Lee - Organization science, 1991 - pubsonline.informs.org
The interpretive approach to organizational research has been gaining increasing attention
as a legitimate alternative to the more traditional positivist approach. The organizational …

[HTML][HTML] The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

…, M Ni, B Lee, E Barron, DR Hinton, AS Lee - Cell Death & …, 2008 - nature.com
… formation induced by ER stress as well as by nutrition starvation was inhibited. GRP78 …
Thus, these studies uncover 3-MA as an inhibitor of UPR activation and establish GRP78 as

Generalizing generalizability in information systems research

AS Lee, RL Baskerville - Information systems research, 2003 - pubsonline.informs.org
Generalizability is a major concern to those who do, and use, research. Statistical, sampling-based
generalizability is well known, but methodologists have long been aware of …

Development and validation of the voice handicap index‐10

CA Rosen, AS Lee, J Osborne, T Zullo… - The …, 2004 - Wiley Online Library
… The goal of the present study was to explore and possibly to develop a shortened VHI as
a vocal function assessment tool both for initial evaluation and for longitudinal assessment of …