User profiles for A. D. Weyer

Andy Weyer

Samuel Merritt University
Verified email at samuelmerritt.edu
Cited by 2200

Piezo2 is required for Merkel-cell mechanotransduction

SH Woo, S Ranade, AD Weyer, AE Dubin, Y Baba… - Nature, 2014 - nature.com
How we sense touch remains fundamentally unknown 1 , 2 . The Merkel cell–neurite
complex is a gentle touch receptor in the skin that mediates slowly adapting responses of Aβ …

[HTML][HTML] Development of TRPM8 antagonists to treat chronic pain and migraine

AD Weyer, SG Lehto - Pharmaceuticals, 2017 - mdpi.com
WeyerWeyer, AD; Lehto, SG Development of TRPM8 Antagonists to Treat Chronic
Pain and Migraine. Pharmaceuticals 2017, 10, 37. https://doi.org/10.3390/ph10020037 …

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

…, L Grundy, GY Rychkov, AD Weyer… - Nature, 2016 - nature.com
Voltage-gated sodium (Na v ) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non-…

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

…, EK Williams, DE Strochlic, S Lee, AD Weyer… - Elife, 2014 - elifesciences.org
10.7554/eLife.04660.001 The somatosensory nervous system is critical for the organism's
ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are …

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

F Moehring, AM Cowie, AD Menzel, AD Weyer… - Elife, 2018 - elifesciences.org
10.7554/eLife.31684.001 The first point of our body’s contact with tactile stimuli (innocuous
and noxious) is the epidermis, the outermost layer of skin that is largely composed of …

Nociceptor sensitization depends on age and pain chronicity

AD Weyer, KJ Zappia, SR Garrison, CL O'Hara… - Eneuro, 2016 - eneuro.org
… Animals were housed in a climate-controlled room with a 14 h:10 h light/dark cycle and
ad libitum access to food and water. All behavioral assays and research protocols involving …

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory-and neuropathic-induced mechanical hypersensitivity in rats

SG Lehto, AD Weyer, BD Youngblood… - Molecular …, 2016 - journals.sagepub.com
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in
pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 …

A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A-and C-fiber neurons

SR Garrison, AD Weyer, ME Barabas, BA Beutler… - PAIN®, 2014 - Elsevier
Therapeutic use of general sodium channel blockers, such as lidocaine, can substantially
reduce the enhanced activity in sensory neurons that accompanies chronic pain after nerve or …

Chemokine (cc motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice

…, KJ Zappia, CL O'Hara, SN Langer, AD Weyer… - Pain, 2018 - journals.lww.com
Approximately one-third of individuals with sickle cell disease (SCD) develop chronic pain.
This debilitating pain is inadequately treated because the underlying mechanisms driving the …

[HTML][HTML] Mechanosensory and ATP release deficits following keratin14-Cre-mediated TRPA1 deletion despite absence of TRPA1 in murine keratinocytes

KJ Zappia, SR Garrison, O Palygin, AD Weyer… - PLoS …, 2016 - journals.plos.org
Keratinocytes are the first cells that come into direct contact with external tactile stimuli;
however, their role in touch transduction in vivo is not clear. The ion channel Transient Receptor …