Membrane protein oligomeric structure and transport function

Nature. 1981 Apr 9;290(5806):449-54. doi: 10.1038/290449a0.

Abstract

Proteins which traverse membranes tend to have a dimeric structure in which the dimer is arranged asymmetrically across the membrane with the axis of symmetry perpendicular to the membrane plane. This general structure is well suited to the function of transporting nutrients across the cell membrane.

MeSH terms

  • Carrier Proteins / physiology*
  • Cell Membrane / physiology*
  • Cell Membrane / ultrastructure
  • Ion Channels / physiology
  • Macromolecular Substances
  • Membrane Lipids
  • Membrane Proteins / physiology*
  • Phospholipids
  • Protein Conformation
  • Sodium-Potassium-Exchanging ATPase / physiology
  • Structure-Activity Relationship

Substances

  • Carrier Proteins
  • Ion Channels
  • Macromolecular Substances
  • Membrane Lipids
  • Membrane Proteins
  • Phospholipids
  • Sodium-Potassium-Exchanging ATPase