Abstract
Evidence for the cholinergic hypothesis of depression is reviewed, arguments directed against this hypothesis are set forth, and the strengths and weaknesses of these criticisms are discussed. The authors conclude that the cholinergic hypothesis is tenable but suggest new areas of study.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acetylcholine / physiology
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Arousal / physiology
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Brain / physiopathology*
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Depressive Disorder / physiopathology*
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Humans
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Receptors, Cholinergic / physiology*
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Receptors, Muscarinic / physiology
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Receptors, Nicotinic / physiology
Substances
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Receptors, Cholinergic
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Receptors, Muscarinic
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Receptors, Nicotinic
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Acetylcholine