Differential effects of NMDA receptor antagonism on spine density

Synapse. 2015 Jan;69(1):52-6. doi: 10.1002/syn.21784. Epub 2014 Oct 6.

Abstract

The authors demonstrate that different NMDAR antagonists (ketamine and MK-801) have varying effects on spine density depending on dose, drug regimen, and brain region. While acute ketamine treatment increases cortical spine density in mice, subchronic exposure to either drug reduces spine density in both the cortex and striatum.

Keywords: MK-801; NMDA receptor; antidepressant; ketamine; spine density.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / cytology
  • Brain / drug effects*
  • Dendritic Spines / drug effects*
  • Dizocilpine Maleate / pharmacology*
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Ketamine / pharmacology*
  • Male
  • Mice, Inbred C57BL
  • Microscopy, Confocal
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*

Substances

  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Ketamine
  • Dizocilpine Maleate