Cortical circuits: layer 6 is a gain changer

Mateo Vélez-Fort; Troy W Margrie

doi:10.1016/j.cub.2012.03.055

Cortical circuits: layer 6 is a gain changer

Curr Biol. 2012 May 22;22(10):R411-3. doi: 10.1016/j.cub.2012.03.055.

Authors

Mateo Vélez-Fort¹, Troy W Margrie

Affiliation

¹ The National Institute for Medical Research, The Ridgeway, London, UK.

PMID: 22625861
DOI: 10.1016/j.cub.2012.03.055

Abstract

Stimulation of excitatory cells in layer six of mouse visual cortex results in net inhibition of the spiking of neurons in upper cortical layers; this ascending intra-cortical drive provides a mechanism for gain modulation of sensory-evoked responses.

MeSH terms

Animals
Mice
Models, Neurological
Neocortex / physiology*
Neural Pathways / physiology
Photic Stimulation
Thalamic Nuclei / physiology
Visual Cortex / physiology*
Visual Perception / physiology*