Abstract
Stimulating sensitized immune cells with a subsequent immune challenge results in potentiated pro-inflammatory responses translating into exacerbated sickness responses (i.e. fever, pain and lethargy). Both corticosterone (CORT) and laparotomy cause sensitization, leading to enhanced sickness-induced neuroinflammation or pain (respectively). However, it is unknown whether this sensitization affects all sickness behaviors and immune cell responses equally. We show that prior CORT and prior laparotomy potentiated LPS-induced fever but not lethargy. Prior CORT, like prior laparotomy, was able to potentiate sickness-induced pain. Release of nitric oxide (NO) from peritoneal macrophages stimulated ex vivo demonstrates that laparotomy, but not CORT sensitizes these cells.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Cells, Cultured
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Corticosterone / administration & dosage*
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Corticosterone / toxicity*
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Drug Synergism
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Fever / chemically induced*
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Fever / immunology
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Fever / pathology
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Gram-Negative Bacterial Infections / chemically induced*
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Gram-Negative Bacterial Infections / immunology
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Gram-Negative Bacterial Infections / pathology
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Host-Pathogen Interactions / immunology
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Immunization
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Inflammation / chemically induced
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Inflammation / immunology
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Inflammation / pathology
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Laparotomy / adverse effects*
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Lipopolysaccharides / administration & dosage*
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Lipopolysaccharides / toxicity*
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / immunology
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Macrophages, Peritoneal / pathology
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Male
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Pain / chemically induced
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Pain / immunology
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Pain / pathology
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Rats
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Rats, Sprague-Dawley
Substances
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Lipopolysaccharides
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Corticosterone