Abstract
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Adult
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Alzheimer Disease / drug therapy
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Amyotrophic Lateral Sclerosis / drug therapy
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Animals
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Brain-Derived Neurotrophic Factor / administration & dosage
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Brain-Derived Neurotrophic Factor / genetics
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Brain-Derived Neurotrophic Factor / physiology
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Brain-Derived Neurotrophic Factor / therapeutic use*
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Cognition / physiology
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Epigenomics
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Genetic Therapy
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Humans
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Huntington Disease / drug therapy
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Mental Disorders / drug therapy*
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Metabolic Diseases / drug therapy
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Nervous System Diseases / drug therapy*
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Parkinson Disease / drug therapy
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Spinal Cord Injuries / drug therapy
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Stroke / drug therapy
Substances
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Brain-Derived Neurotrophic Factor