Abstract
Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / genetics
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Alzheimer Disease / metabolism
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Alzheimer Disease / physiopathology
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Animals
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Axonal Transport / genetics*
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Axons / metabolism*
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Axons / pathology
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Central Nervous System / metabolism*
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Central Nervous System / pathology
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Central Nervous System / physiopathology
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Charcot-Marie-Tooth Disease / genetics
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Charcot-Marie-Tooth Disease / metabolism
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Charcot-Marie-Tooth Disease / physiopathology
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Humans
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Huntington Disease / genetics
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Huntington Disease / metabolism
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Huntington Disease / physiopathology
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Motor Neuron Disease / genetics
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Motor Neuron Disease / metabolism
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Motor Neuron Disease / physiopathology
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Neurodegenerative Diseases / genetics*
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Neurodegenerative Diseases / metabolism*
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Neurodegenerative Diseases / physiopathology
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Parkinson Disease / genetics
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Parkinson Disease / metabolism
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Parkinson Disease / physiopathology