A parameter-space search algorithm tested on a Hodgkin-Huxley model

Biol Cybern. 2007 Jun;96(6):625-34. doi: 10.1007/s00422-007-0156-2. Epub 2007 May 9.

Abstract

We demonstrate a parameter-space search algorithm using a computational model of a single-compartment neuron with conductance-based Hodgkin-Huxley dynamics. To classify bursting (the desired behavior), we use a simple cost function whose inputs are derived from the frequency content of the neural output. Our method involves the repeated use of a stochastic gradient descent-type algorithm to locate parameter values that allow the neural model to produce bursting within a specified tolerance. We demonstrate good results, including those showing that the utility of our algorithm improves as the pre-defined allowable parameter ranges increase and that the initial approach to our method is computationally efficient.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Algorithms*
  • Animals
  • Computer Simulation
  • Fourier Analysis
  • Models, Neurological*
  • Neural Networks, Computer
  • Neurons / physiology*
  • Time Factors