Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells

Mol Cell Neurosci. 2007 Feb;34(2):261-70. doi: 10.1016/j.mcn.2006.11.006. Epub 2006 Dec 22.

Abstract

Spinocerebellar ataxia type 6 (SCA6) is caused by polyglutamine expansion in P/Q-type Ca2+ channels (Ca(v)2.1) and is characterized by predominant degeneration of cerebellar Purkinje cells. To characterize the Ca(v)2.1 channel with an SCA6 mutation in cerebellar Purkinje cells, we have generated knock-in mouse models that express human Ca(v)2.1 with 28 polyglutamine repeats (disease range) and with 13 polyglutamine repeats (normal range). Patch-clamp recordings of the Purkinje cells from homozygous control or SCA6 knock-in mice revealed a non-inactivating current that is highly sensitive to a spider toxin omega-Agatoxin IVA, indicating that the human Ca(v)2.1 expressed in Purkinje cells exhibits typical P-type properties in contrast to the previous data showing Q-type properties, when it was expressed in cultured cell lines. Furthermore, the voltage dependence of activation and inactivation and current density were not different between SCA6 and control, though these properties were altered in previous reports using non-neuronal cells as expression systems. Therefore, our results do not support the notion that the alteration of the channel properties may underlie the pathogenic mechanism of SCA6.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Behavior, Animal / physiology
  • Calcium Channel Blockers / pharmacology
  • Calcium Channels / metabolism*
  • Calcium Channels, N-Type / physiology*
  • Cells, Cultured
  • Cerebellum / cytology
  • Electric Stimulation / methods
  • Gene Expression Regulation / physiology
  • Gene Expression Regulation / radiation effects*
  • Humans
  • In Situ Hybridization
  • Membrane Potentials / genetics
  • Mice
  • Mice, Transgenic
  • Motor Activity / genetics
  • Mutation / physiology*
  • Patch-Clamp Techniques / methods
  • Peptides / genetics
  • Purkinje Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • omega-Agatoxin IVA / pharmacology

Substances

  • CACNA1A protein, human
  • Calcium Channel Blockers
  • Calcium Channels
  • Calcium Channels, N-Type
  • Peptides
  • omega-Agatoxin IVA
  • voltage-dependent calcium channel (P-Q type)
  • polyglutamine