Endotoxin recognition and signal transduction by the TLR4/MD2-complex

Microbes Infect. 2004 Dec;6(15):1361-7. doi: 10.1016/j.micinf.2004.08.015.

Abstract

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Surface / metabolism*
  • Antigens, Surface / physiology
  • Carrier Proteins / metabolism*
  • Carrier Proteins / physiology
  • Endotoxins / metabolism
  • Lipopolysaccharides / pharmacology
  • Lymphocyte Antigen 96
  • Membrane Glycoproteins / metabolism*
  • Membrane Glycoproteins / physiology
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cell Surface / physiology
  • Signal Transduction / physiology*
  • Toll-Like Receptor 4
  • Toll-Like Receptors

Substances

  • Antigens, Surface
  • Carrier Proteins
  • Endotoxins
  • Lipopolysaccharides
  • Lymphocyte Antigen 96
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptor 4
  • Toll-Like Receptors