Abstract
A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.
Publication types
-
Comparative Study
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Action Potentials / physiology
-
Animals
-
Benzimidazoles / metabolism
-
Chlorides / metabolism
-
Drug Interactions
-
Excitatory Postsynaptic Potentials / physiology
-
Excitatory Postsynaptic Potentials / radiation effects
-
GABA Antagonists / pharmacology
-
Ganglia, Invertebrate / cytology
-
Gap Junctions / physiology
-
Gap Junctions / radiation effects
-
Glycyrrhetinic Acid / pharmacology
-
Microscopy, Electron, Transmission / methods
-
Models, Neurological*
-
Mollusca
-
Neural Inhibition / physiology
-
Neurons / classification
-
Neurons / physiology*
-
Odorants
-
Olfactory Bulb / metabolism
-
Olfactory Bulb / physiology*
-
Olfactory Bulb / ultrastructure
-
Patch-Clamp Techniques / methods
-
Periodicity*
-
Picrotoxin / pharmacology
-
Synaptic Transmission / physiology
-
Time Factors
Substances
-
Benzimidazoles
-
Chlorides
-
GABA Antagonists
-
hoechst 32258
-
Picrotoxin
-
Glycyrrhetinic Acid