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Neuropediatrics 1996; 27(4): 171-173
DOI: 10.1055/s-2007-973781
Original Articles

© Hippokrates Verlag GmbH Stuttgart

Add-On Therapy of Fenfluramine in Intractable Self-Induced Epilepsy

M. Boel, P. Casaer
  • Paediatric Rehabilitation and Epilepsy Unit, Reebergenlaan 4, Pulderbos, Belgium
  • Department of Paediatrics, Section of Paediatric Neurology Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
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Publication History

Publication Date:
13 March 2007 (online)

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Abstract

Eleven institutionalized children (7 girls, 4 boys) with refractory epilepsy received fenfluramine as addon therapy.

Besides therapy resistance, the patients manifested self-induction of seizures. Eight patients were photosensitive and/or pattern sensitive. All antiepileptic drugs of doubtful efficacy were withdrawn. During withdrawal, patients did neither improve nor show an increase in seizure frequency.

Fenfluramine was then added and administered once to three times daily at dosages between 0.5 and 1 mg/kg.day.

Side effects were mild and transient. Of the 11 patients, 7 became seizure-free and in 4 patients a more than 75 % decrease of all seizures was obtained.

Key words

Epilepsy - Photosensitivity - Childhood Self-induction - Fenfluramine

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