Abstract
Cells throughout the CNS have synchronous activity patterns; that is, a cell's probability of generating an action potential depends both on its firing rate and on the occurrence of action potentials in surrounding cells. The mechanisms producing synchronous or correlated activity are poorly understood despite its prevalence and potential effect on neural coding. We found that neighboring parasol ganglion cells in primate retina received strongly correlated synaptic input in the absence of modulated light stimuli. This correlated variability appeared to arise through the same circuits that provide uncorrelated synaptic input. In addition, ON, but not OFF, parasol cells were coupled electrically. Correlated variability in synaptic input, however, dominated correlations in the parasol spike outputs and shared variability in the timing of action potentials generated by neighboring cells. These results provide a mechanistic picture of how correlated activity is produced in a population of neurons that are critical for visual perception.
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Acknowledgements
We thank J. Cafaro, E.J. Chichilnisky, G. Murphy, E. Shea-Brown and J. Shlens for comments on the manuscript and for enlightening discussions; D. Carleton, E. Martinson and P. Newman for excellent technical assistance; and Dennis Dacey, Joanna Crook, Orin Packer, Toni Haun and Beth Peterson for providing primate tissue. Support was provided by the Howard Hughes Medical Institute and the US National Institutes of Health (EY-11850).
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F.R. conducted the experiments. P.K.T. and F.R. analyzed the data and wrote the manuscript.
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Trong, P., Rieke, F. Origin of correlated activity between parasol retinal ganglion cells. Nat Neurosci 11, 1343–1351 (2008). https://doi.org/10.1038/nn.2199
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DOI: https://doi.org/10.1038/nn.2199
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