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Peli1 sets the CNS on fire

Nature Medicine volume 19, pages 536–538 (2013)Cite this article

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It has long been unknown how activation of resident macrophages in the brain, or microglia, is regulated during the inflammatory pathogenesis of multiple sclerosis. Work in a mouse model of human multiple sclerosis identifies the E3 ubiquitin ligase Peli1 as a new crucial regulator of microglia activation (pages 595–602).

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Figure 1: Peli1-mediated regulation of microglia activation.

Katie Vicari

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Authors and Affiliations

  1. Xinyang Song and Youcun Qian are at the Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China.,

    Xinyang Song & Youcun Qian

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  1. Xinyang Song
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  2. Youcun Qian
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Correspondence to Youcun Qian.

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The authors declare no competing financial interests.

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Song, X., Qian, Y. Peli1 sets the CNS on fire. Nat Med 19, 536–538 (2013). https://doi.org/10.1038/nm.3176

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