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The role of dendrites in auditory coincidence detection

Nature volume 393, pages 268–272 (1998)Cite this article

Abstract

Coincidence-detector neurons in the auditory brainstem of mammals and birds use interaural time differences to localize sounds1,2. Each neuron receives many narrow-band inputs from both ears and compares the time of arrival of the inputs with an accuracy of 10–100 µs (3–6). Neurons that receive low-frequency auditory inputs (up to about 2 kHz) have bipolar dendrites, and each dendrite receives inputs from only one ear7,8. Using a simple model that mimics the essence of the known electrophysiology and geometry of these cells, we show here that dendrites improve the coincidence-detection properties of the cells. The biophysical mechanism for this improvement is based on the nonlinear summation of excitatory inputs in each of the dendrites and the use of each dendrite as a current sink for inputs to the other dendrite. This is a rare case in which the contribution of dendrites to the known computation of a neuron may be understood. Our results show that, in these neurons, the cell morphology and the spatial distribution of the inputs enrich the computational power of these neurons beyond that expected from ‘point neurons’ (model neurons lacking dendrites).

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Figure 1: A point-neuron model for auditory coincidence detectors.
Figure 2: A bipolar-neuron model for coincidence detection.
Figure 3: Biophysical mechanism and frequency dependence.
Figure 4: Bipolar integrate-and-fire model.

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Acknowledgements

This work was supported by grants from the NIH (to C.E.C.) and the Human Frontier Science Program (to H.A.-S.). We thank G. Gerstein, I. Nelken, E. W. Rubel, D. Sanes and I. Segev for comments, and the NCI Biomedial Supercomputing Center at Frederick for computer resources and technical help.

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Author notes

  1. John Rinzel

    Present address: New York University, Center for Neural Science and Courant Institute of Mathematical Sciences, New York, 10003, USA

Authors and Affiliations

  1. Mathematical Research Branch, NIDDK, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Hagai Agmon-Snir & John Rinzel

  2. Department of Zoology, University of Maryland, College Park, 20742, Maryland, USA

    Catherine E. Carr

Authors
  1. Hagai Agmon-Snir
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  2. Catherine E. Carr
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  3. John Rinzel
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Correspondence to Catherine E. Carr.

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Agmon-Snir, H., Carr, C. & Rinzel, J. The role of dendrites in auditory coincidence detection. Nature 393, 268–272 (1998). https://doi.org/10.1038/30505

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