Elsevier

Vision Research

Volume 44, Issue 28, December 2004, Pages 3401-3410
Vision Research

Using eye movements to assess brain function in mice

https://doi.org/10.1016/j.visres.2004.09.011Get rights and content
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Abstract

Examining eye movements is an important part of the neurological evaluation of humans; the distribution of the neural circuits that control these movements is such that they are disrupted—often in highly characteristic fashions—by many disease processes. Technical advances have made it possible to measure accurately the eye movements of mice, so it is now possible to use the detective power of eye movement recording to characterize neurological dysfunction in genetically altered strains. Here we introduce analytical tools used in ocular motor research and demonstrate their ability to reveal disorders of the visual pathways, inner ear, and cerebellum.

Keywords

Vestibular
Optokinetic
Rd1 gene
Mutant mouse
Oculomotor

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