Trends in Neurosciences
Review
INMED/TINS special issueAre corticothalamic ‘up’ states fragments of wakefulness?
INMED/TINS special issue
Introduction
The function of sleep is a mystery that has long fascinated biologists and is still the matter of intense debate [1]. One of the most prominent features of sleep in mammals is the occurrence of the slow (<1 Hz) sleep oscillation that dominates slow-wave sleep (SWS; Box 1). This oscillation is extremely similar in different species 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, suggesting that it might have well-defined, conserved roles. Fairly recently, behavioural experiments have indicated that SWS might be related to memory consolidation 11, 12, 13, 14, 15, 16, 17 and the basis of such consolidation might be the slow sleep oscillation itself 12, 14, 15, 16, 17, 18. Here, we explore this issue from an electrophysiological and computational modelling perspective. Specifically, we reassess various electrophysiological measurements of the waking (or wake-like) state and compare them with those obtained for the ‘up’ state of the slow (<1 Hz) sleep oscillation in the specific brain structures involved in its generation. The extremely close similarity of both single-neuron and network dynamics during these different scenarios is compatible with the results of behavioural experiments indicating that during SWS selected epochs of prior experience are episodically replayed and consolidated.
Section snippets
The dynamics of single neurons during ‘activated’ states and slow-wave sleep
We start by reviewing the essential cellular correlates of the ‘activated’ brain state, which corresponds to attentive wakefulness, and examine how they qualitatively compare with those of SWS. Brain activation is invariably associated with a so-called ‘desynchronized’ electroencephalogram (EEG), which consists of low-amplitude fluctuations at relatively high frequencies (>15 Hz) 5, 6 (Figure 1a). This state is associated with tonic and irregular firing of cortical neurons [19], the membrane
Similarities in cortical network dynamics between the ‘activated’ state and ‘up’ states of the slow oscillation
The similarity between activated states and the slow-oscillation ‘up’ state in the cortex is not only apparent at the rank of single cells, but can also be found at the level of the EEG and local field potentials (LFPs) (see Glossary). First, the typical desynchronized EEG pattern of arousal is evident locally in the EEG during ‘up’ states, both in the naturally sleeping animal (Figure 1a) and during anaesthesia (Figure 1b). A second, and stronger, indication of the similarities comes from
Similarities between a persistently depolarized state and the ‘up’ state of the slow oscillation in thalamocortical and thalamic reticular nucleus neurons
Both cortical and thalamic slow (<1 Hz) oscillations can be reproduced using in vitro models. In cortical slices, the slow oscillation is reliant on a modified, artificial cerebrospinal fluid, containing a reduced Ca2+ concentration, and is generated primarily by network-dependent mechanisms 24, 42 (see Glossary). In thalamic slices, by contrast, the slow oscillation in both TC and TRN neurons is generated mainly by intrinsic mechanisms 9, 43, 44, 45, 46 (see Glossary). These oscillations have
Slow-oscillation ‘up’ states as micro-wake ‘fragments’
An assortment of data from the corticothalamic system has been presented that converges to establish that, at both single-cell and neuronal-network levels, the fully activated brain state and slow-oscillation ‘up’ states are dynamically similar. An attractive interpretation of this is that individual corticothalamic ‘up’ states provide micro-wake-like contexts that facilitate specific types of neuronal interaction. In particular, they might provide brief epochs of network dynamics that aid the
T-type Ca2+ channel-mediated bursts in thalamocortical neurons as a trigger for ‘up’ states and synaptic plasticity
If individual ‘up’ states contain segments of prior wake-related dynamics, an attractive hypothesis is that these segments are determined and selected during wakefulness through ongoing remodelling of cortical [59] or corticothalamic attractors by sensory input [18]. Such attractors might then be preferentially activated in sleep during the slow-oscillation ‘up’ state [18], particularly in response to a strong thalamic signal, which is a highly effective way to trigger internally defined
Concluding remarks
Electrophysiological and modelling data show that ‘up’ states of the slow (<1 Hz) sleep oscillation are dynamically equivalent to the activated state of wakefulness. This is in agreement with several behavioural investigations, which indicate that waking activities are replayed, and possibly consolidated, during SWS. The prominent T-type Ca2+ channel-mediated bursts in TC neurons might function as key network triggers that ensure the synchronous start of slow-oscillation ‘up’ states across
Acknowledgements
This review is dedicated to the memory of Mircea Steriade. Work in our laboratories is supported by The Wellcome Trust (grants 71436, 78311 and 78403 to V.C. and S.W.H. and the CNRS, Human Frontier Science Program and European Community (A.D. and M.R.). Additional information regarding other published work from our laboratories is available at http://www.thalamus.org.uk and http://cns.iaf.cnrs-gif.fr.
References (66)
- et al.
Low-frequency (<1 Hz) oscillations in the human sleep electroencephalogram
Neuroscience
(1997) Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons
Neuroscience
(2006)- et al.
Memory of sequential experience in the hippocampus during slow wave sleep
Neuron
(2002) Firing rate modulation: a simple statistical view of memory trace reactivation
Neural Netw.
(2005)- et al.
Cortical unit activity in sleep and waking
Electroencephalogr. Clin. Neurophysiol.
(1971) Selective GABAergic control of higher-order thalamic relays
Neuron
(2005)Integration and segregation of activity in entorhinal–hippocampal subregions by neocortical slow oscillations
Neuron
(2006)- et al.
Simulating cortical network activity states constrained by intracellular recordings
Neurocomputing
(2004) Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
Neuron
(2002)Thalamic T-type Ca2+ channels and NREM sleep
Cell Calcium
(2006)
Synchronized oscillations at α and ϑ frequencies in the lateral geniculate nucleus
Neuron
Neuromodulation: acetylcholine and memory consolidation
Trends Cogn. Sci.
Coordinated interactions between hippocampal ripples and cortical spindles during slow-wave sleep
Neuron
Internal dynamics determine the cortical response to thalamic stimulation
Neuron
Why do we sleep?
Brain Res.
Sleep is of the brain, by the brain and for the brain
Nature
Slow sleep oscillation, rhythmic K-complexes, and their paroxysmal developments
J. Sleep Res.
Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep
J. Neurosci.
Natural waking and sleep states: a view from inside neocortical neurons
J. Neurophysiol.
Disfacilitation and active inhibition in the neocortex during the natural sleep–wake cycle: an intracellular study
Proc. Natl. Acad. Sci. U. S. A.
Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking α1G-subunit of T-type calcium channels
Proc. Natl. Acad. Sci. U. S. A.
Communication between neocortex and hippocampus during sleep in rodents
Proc. Natl. Acad. Sci. U. S. A.
Hippocampal slow oscillation: a novel EEG state and its coordination with ongoing neocortical activity
J. Neurosci.
Elevated sleep spindle density after learning or after retrieval in rats
J. Neurosci.
Coordinated memory replay in the visual cortex and hippocampus during sleep
Nat. Neurosci.
Local sleep and learning
Nature
Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations
Proc. Natl. Acad. Sci. U. S. A.
Boosting slow oscillations during sleep potentiates memory
Nature
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Nat. Neurosci.
Cellular substrates and laminar profile of sleep K-complex
Neuroscience
The slow (<1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks
J. Neurosci.
Intracellular analysis of relations between the slow (<1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram
J. Neurosci.
A novel slow (<1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components
J. Neurosci.
Cited by (269)
Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development
2024, Neuroscience and Biobehavioral ReviewsSleep-Related Hallucinations
2024, Sleep Medicine ClinicsWhat is sleep exactly? Global and local modulations of sleep oscillations all around the clock
2023, Neuroscience and Biobehavioral ReviewsHow we sleep: From brain states to processes
2023, Revue NeurologiqueUpdating memories of unwanted emotions during human sleep
2023, Current Biology