Elsevier

Psychiatry Research

Volume 219, Issue 2, 30 October 2014, Pages 403-405
Psychiatry Research

Letter to the Editor
Haplotype-tag single nucleotide polymorphism analysis of the Vesicular Glutamate Transporter (VGLUT) genes in severely alcoholic women

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Acknowledgements

The authors thank the participants, as well as Assoc. Prof. Skalkidou Alkistis and Prof. Sundström-Poromaa Inger, Department of Women׳s & Children׳s Health, Uppsala University, for providing the biological material for the control sample. This work was supported by grants from the Swedish Council for Working Life and Social Research to E.C. (2011-0627), and from the Swedish Medical Research Council (2007-5742 (2008-Uppsala University (2009-2014))), the Swedish Brain Foundation (2009, 2012) and

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    Furthermore, preadolescent rat binged alcohol showed an increase in gene expression of vesicular glutamate transporter-1, Vglut1, and reduced Vglut2 and Vglut3 gene expression in the dorsal raphe nucleus (DRN) in P rats [For review see (Bell et al., 2016)]. It has been found that chronic and severe exposure to alcohol is associated with a SNP in vglut1 in female (Comasco et al., 2014). A genetic variant of GLT-1 was associated with dysregulated behaviors and cirrhosis in alcoholics (Foley et al., 2004; Sander et al., 2000).

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