Research paperSystems neuroscienceDopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking
Section snippets
Subjects
Male Sprague–Dawley rats (Charles River, Wilmington, MA, USA), weighing 275–350g at the time of surgery, were housed individually on a reverse light/dark cycle. Rats were maintained on 20–25g of rat chow per day, with water available ad libitum. All protocols were approved by the Institutional Animal Care and Use Committee of the Medical University of South Carolina and carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (National
Histology
A schematic indicating the placement of the infusion cannulae tips of animals that received bilateral SCH23390, raclopride, or vehicle into the BLA is shown in Fig. 1. Subjects with cannulae tracts that did not meet the criteria of bilateral BLA placement are also included in the schematic and the data from these animals were used as an anatomical control group (histology outliers). These animals were fairly evenly distributed over all nine of the treatment groups (n=1–4) and the anatomical
Discussion
In the present study, we examined the role of BLA DA receptors in the formation of cocaine-cue associations in rats trained to self-administer i.v. cocaine and in the subsequent conditioned-cued reinstatement of cocaine-seeking behavior. DA D1 receptor blockade within the BLA during a single cocaine-cue pairing session attenuated the later expression of conditioned-cued reinstatement. DA D2 receptor blockade within the BLA prior to the cocaine-cue pairing session had unique dose-dependent
Acknowledgments
This research was supported by National Institute on Drug Abuse grant DA10462 (R.E.S.) and NIH grant C06 RR015455 from the Extramural Research Facilities Program of the National Center for Research Resources.
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