Mini-reviewTo the descending pain-control system in rats, inflammation-induced primary and secondary hyperalgesia are two different things☆
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Cited by (39)
Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel
2020, Journal of EthnopharmacologyAqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced mono-arthritis: Evidence from in vivo and in vitro studies.
2019, Journal of EthnopharmacologyCitation Excerpt :It was noticed that plant extracts were efficient both at the injected ankle and at the paw, indicating analgesic effect both on primary and secondary hyperalgesia. A differential modulation of the two types of hyperalgesia are now well documented (Treede and Magerl, 2000; Vanegas, 2004). Cumulative evidence shows that secondary hyperalgesia especially in inflammatory arthritis, is due to central sensitization and involves myelinated A-fibers (Walker et al., 2007; Hsieh et al., 2015; Van den Broeke et al., 2016).
Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals
2013, Brain Research BulletinCitation Excerpt :Interestingly, Urban and Gebhart (1999) reported that blocking the RVM reversed secondary hyperalgesia (i.e., hyperalgesia adjacent to the injured region) to heat in monoarthritic or mustard oil-treated animals but failed to reduce primary hyperalgesia (i.e., hyperalgesia in the injured region) in animals with paw inflammation. This result is in line with the hypothesis that the RVM-mediated descending modulation of spinal nociception may vary from inhibition to facilitation depending on whether the spinal neuron receives inputs from the inflamed/injured area or from adjacent areas, respectively (Vanegas, 2004; Vanegas and Schaible, 2004). The dorsomedial nucleus of the hypothalamus (DMH) is among the supramedullary structures that have been shown to contribute to descending pain control through a relay in the RVM (Heinricher et al., 2009).
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia
2013, NeuroscienceCitation Excerpt :It is not known if CCK receptors they are located on neurons that possess NK-1Rs or on separate neurons. The same is true for other neurotransmitter systems that contribute to descending facilitation from the RVM, including neurotensin (Fields et al., 1991; Smith et al., 1997; Urban and Gebhart, 1997; Vanegas, 2004), brain-derived neurotrophic factor (Guo et al., 2006), and tumor necrosis factor-alpha (Wei et al., 2008). Further studies of anatomical and neurochemical mechanisms of multiple descending facilitatory pathways and their interactions are needed.
Changes in response properties of rostral ventromedial medulla neurons during prolonged inflammation: Modulation by neurokinin-1 receptors
2012, NeuroscienceCitation Excerpt :Descending pathways were initially shown to decrease pain transmission and produce antinociception (Criswell, 1976; Basbaum and Fields, 1978, 1984; Dostrovsky et al., 1983; Aimone and Gebhart, 1986; Behbehani, 1995). However, it is now accepted that descending systems can also facilitate nociceptive transmission and contribute to hyperalgesia (see reviews by Porreca et al. (2002), Vanegas (2004) and Suzuki et al. (2004a)). The RVM, which includes the Nucleus Raphe Magnus, the Nucleus Reticularis Gigantocellularis, the Nucleus Gigantocellularis pars alpha, and the Nucleus Paragigantocellularis lateralis, plays an important role in spinal nociceptive processing as a relay structure of descending modulation (Basbaum and Fields, 1984; Fields et al., 1991; Watkins et al., 1998; Urban and Gebhart, 1999; Urban et al., 1999a,b; Millan, 2002), including facilitation of nociceptive transmission and the development of hyperalgesia.
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An Manfred Zimmermann zum 70. Geburstag gewidmet.