ReviewNucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Section snippets
Motivational processes, behavioral activation and effort
Motivation has been defined as the set of processes through which organisms regulate the probability, proximity and availability of significant stimuli (Salamone, 1992, Salamone and Correa, 2002, Salamone and Correa, 2012). Organisms are often separated from significant stimuli in their environment, such as food, water, and sex, by environmental constraints or obstacles (i.e., response or procurement “costs”), and they must overcome such costs in order to gain access to these stimuli. Thus,
Nucleus Accumbens (NAc) dopamine (DA), behavioral activation, and exertion of effort
Considerable evidence indicates that DA, particularly in NAc, regulates behavioral activation and effort-related processes (i.e., processes involved in overcoming work-related response costs; Salamone et al., 1991, Salamone et al., 2003, Salamone et al., 2005, Salamone et al., 2007, Vezina et al., 2002, Zhang et al., 2003, Kelley et al., 2005, Barbano and Cador, 2006, Barbano and Cador, 2007, Floresco et al., 2008, Phillips et al., 2007). It has been suggested that highly active instrumental
NAc DA and effort-related choice
In a complex environment that offers multiple reinforcers, and distinct paths for obtaining them, organisms must make effort-related decisions involving cost/benefit assessments across a wide variety of stimuli and instrumental responses (Salamone et al., 1991, Salamone et al., 1997, Salamone et al., 2003, Salamone et al., 2005, Salamone et al., 2007, Walton et al., 2006, Phillips et al., 2007). Several lines of evidence indicate that NAc DA is involved in aspects of effort-related choice
Neural circuitry involved in effort-related processes
Although NAc DA is a vital component of the brain circuitry regulating work output and effort-related choice behavior, other brain areas and neurotransmitters also are involved. Several studies have employed the T-maze procedure described above to investigate the role of both cortical and sub-cortical structures in effort-related choice. Lesions of the medial frontal cortex, including selective lesions to the anterior cingulate cortex (ACC), cause rats to shift their choice from the high
Adenosine/DA interactions involved in effort-related processes
Within the last few years, increasing evidence has accumulated indicating that central adenosine neurotransmission plays an important role in modulating the functional circuitry of the basal ganglia (Ferré et al., 1997, Svenningsson et al., 1999, Hauber et al., 2001, Salamone et al., 2010). Anatomical studies have demonstrated that the adenosine A2A receptor subtype has a relatively high degree of expression within both the neostriatum and the NAc (Svenningsson et al., 1999, Wang et al., 2000,
The role of NAc muscarinic receptors in effort-related processes
As described above, considerable evidence indicates that drugs acting on DA and adenosine A2A receptors can affect effort-related choice behavior. However, another important neurotransmitter present in the entire striatal complex, including the NAc, is acetylcholine (ACh; Pisani et al., 2007). NAc ACh has been implicated in a variety of behaviors that include habit formation, aversive behavioral reactions, control of locomotor activity, and the regulation of motivation and affect (Schildein et
The neural circuitry of effort-related choice behavior: implications for understanding motivational impairments in depression.
In summary, considerable evidence demonstrates that NAc is an important striatal site at which drugs acting on DA, adenosine A2A, and muscarinic ACh receptors can modify effort-related choice behavior. For example, using the concurrent FR5/chow feeding choice task, interference with DA transmission by local DA depletion or antagonism (Salamone et al., 1991, Sokolowski and Salamone, 1998, Nowend et al., 2001, Farrar et al., 2010), as well as stimulation of NAc core adenosine A2A (Font et al.,
Acknowledgements
We wish to dedicate this paper to the memory of our esteemed colleague and dear friend, Dr. Ann Kelley. Also, we wish to thank Evan Hart and Myles Jones for their assistance with this research. This work was supported by a grant to J.S. from the National Institute of Mental Health (MH094966), and to Mercè Correa from Fundació Bancaixa/U. Jaume I. (P1.1B2010-43).
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