Short communicationThe medial preoptic area modulates cocaine-induced locomotion in male rats
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Conflict of interest
The authors declare no conflict of interest.
Acknowledgments
This project was funded by NIDA grant R01-DA032789 to JMD. RGW is on NIAAA training grant T32-AA007471. JRM was awarded an Undergraduate Research Fellowship from the Office of the Vice President for Research, The University of Texas at Austin. Parts of this study were performed as fulfillment of JRM’s Honors Thesis. We wish to thank Dr. Chris Robison for comments on an earlier version of this manuscript.
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2023, Hormones and BehaviorCitation Excerpt :This cocaine dose was chosen because it is a moderate dose on the upper ascending limb of the dose response curve that has previously been shown to produce sex differences in locomotor response in intact rats (Walker et al., 2001). In addition, our laboratory has used this dose in prior studies of both males and females (Will et al., 2016; Robison et al., 2018). Rats were tested 1–5 h after the start of the dark cycle in a room with ambient-white noise.
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Estradiol increases choice of cocaine over food in male rats
2019, Physiology and BehaviorCitation Excerpt :Several studies by Becker and colleagues have demonstrated estradiol in females modulates dopamine release in the striatum by acting on medium spinal neurons within these regions (reviewed in [54]) with preliminary experiments suggesting a somewhat more limited effects in males [55]. More recently, Dominguez and colleagues have demonstrated that MPOA regulates cocaine-induced locomotor responses in male rats [58] and cocaine-induced conditioned place preferences in female rats [48]. Further, administration of estradiol into the MPOA enhances cocaine-induced increases in dopamine within the nucleus accumbens [49] as well as cocaine-induced conditioned place preferences [44].
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2018, Hormones and BehaviorCitation Excerpt :The medial preoptic area (MPOA) may regulate some of the effects of estradiol on ventral striatal DA activity. ER positive cells in the MPOA have been shown to project to the VTA, and inhibit DA release in the NAc (Will et al., 2016). The effect of estradiol on DA release in response to cocaine was diminished after lesions of the MPOA, and estradiol microinjections in the MPOA enhanced cocaine induced DA release in female rats (Tobiansky et al., 2015).
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