Elsevier

Vision Research

Volume 42, Issue 2, January 2002, Pages 151-157
Vision Research

Rat retinal ganglion cells co-express brain derived neurotrophic factor (BDNF) and its receptor TrkB

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Abstract

The expression of brain derived neurotrophic factor (BDNF) and its preferred receptor (TrkB) in rat retinal ganglion cells (RGCs) have been determined in the present study. To identify RGCs retrograde labelling was performed with fluorogold (FG). Subsequently, retinas were immunostained with antibodies to BDNF and TrkB. We found that all RGCs labelled with FG express both BDNF and its preferred receptor, TrkB. Moreover, displaced amacrine cells were also found to be immunolabelled by both antibodies. Thus BDNF/TrkB signalling in RGCs probably involves endogenous BDNF produced by the RGCs themselves.

Keywords

Brain derived neurotrophic factor
TrkB
Ganglion cell
Retina
Fluorogold
Neurotrophin
Receptor

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